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In a recent clinical trial using ex vivo grown MKs after culture with SCF, MGDF, and thus hIL3,wedge shoes, Generated grafts contained up to 3 CD41+ cells in patients use nonmyeloablative intensification regimens.20 nonetheless, This study also showed the absence of clinical efficacy in terms of shortening thrombocytopenia, Suggesting that clinically useful ex vivo expansion of functional and proplateletforming MKs will be a struggle in clinically acceptable conditions. The culture conditions could in parallel be modified according to the future availability of welldefined lipids and/or other cytokines to improve the quality of the MKs generated ex vivo,ostrich pillow buy, Despite the presence of proplateletforming MKs that we observed in preclinical conditions, The optimal maturation might possibly not have been achieved in largescale cultures.in summary, Ex vivo expansion of MK progenitor cells in clinically acceptable provisions is feasible and could be used to treat patients receiving an autograft as a salvage therapy for relapsed lymphoma. this process was safe but failed to prevent thrombocytopenia l.
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