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CIK cells show strong cytotoxic activity against various tumor target cell lines including B and T lymphomas and myeloid leukemias. more importantly, enlarged cord bloodderived CIK cells are cytotoxic against fresh leukemic blasts and express perforin, Granzyme and NKG2D particle at high levels. The same in vitro protocol has already been used to expand CIK cells from peripheral blood of adult donors under GMP conditions and therefore these observations open up regarding imagining a future clinical application of leukemia relapse following cord blood transplantation with CIK cells obtained from the same cord blood unit,
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